The comprehensive study was found out to evaluate the concentration of different water qualities of the Karnaphuli river. Samples were collected from ten points (Bhandor Ghat to Bhakoliya Khal Ghat) in three seasons (winter, rainy, and spring) during the Hydrological Year 2014-2015 for continuous monitoring. Collected samples were analyzed for finding of some physicochemical parameters Temperature, pH, Alkalinity, Acidity, Total hardness, Sulfate, Chloride, Total Dissolved Solids (TDS), and CO 2 . The investigated parameters were compared to the national and international standards. The mean values of water Temperature, pH, Alkalinity, Acidity, Total hardness, Phosphorus, Sulfate, Chloride, TDS, and free CO 2 were found to be 28. 36° C, 6.25, 275.63ppm, 19.75ppm, 259.29ppm, 0.904ppm, 70.74ppm, 534.63ppm, 778.83ppm & 18.03ppm, respectively. Water Quality Index (WQI), Langelier Saturation Index (LSI) and Ryznar Stability Index (RSI) values were found to be 99.92, −3.06 & 12.36, respectively, which indicate that the water quality is not good.