Overall, 25% and 13% of isolates were MDR and multi-azole resistant, respectively. The most common resistance combination was azoles and 5-flucytosine in 14% followed by azoles and amphotericin B in 7% and azoles and echinocandins in 2% of isolates.

Candida auris is an emerging fungus that presents a serious threat to global health. The organism is difficult to identify using conventional biochemical methods. C. auris has also attracted attention because of its reduced susceptibility to azoles, polyenes, and echinocandins, with a few strains even resistant to all three classes of antifungals. In this review paper we discuss the trends in emergence of C. auris in different parts of the world, associated risk factors, drug resistance, and diagnostic challenges. Strategies for prevention and therapeutic options for such infections is also addressed.

A novel coronavirus infection, which began as an outbreak of unusual viral pneumonia in Wuhan, a central city in China, has evolved into a global health crisis. The outbreak is an unembellished reminder of the hazard coronaviruses pose to public health. Government and researchers around the world have been taking swift measures to control the outbreak and conduct aetiological studies to understand the various facets of the outbreak. This review is an attempt at providing an insight about the current understanding, knowledge gaps and a perspective on the future of coronavirus disease 2019 (COVID-19) infections. All the authentic data published so far on COVID-19 has been systematically analysed. PubMed, NCBI, World Health Organisation, Ministry of Health and Family Welfare (India), and Centers for Disease Control and Prevention databases and bibliographies of relevant studies up to 22 nd June 2020 have been included. The Wuhan outbreak is a stark reminder of the continuing threat posed by zoonotic diseases to global health. Despite an armamentarium of Government officials, researchers and medical fraternity working towards the containment of this novel coronavirus viral pneumonia continues to spread at an alarming rate infecting multitudes and claiming hundreds of lives.

Neuroanatomical and hormonal peculiarities of women are cause of higher prevalence of depression in females compared to males. Endogenous estrogen and progesterone have a profound effect on neurophysiology and neural pathways, this is the reason why depression is more common at the time of hormonal fluctuations, such as premenstrual, postpartum, premenopausal. Unique differences in life experiences, tem perament and biology suggests no single treatment is effective for everyone, combination of psychotherapy and medications should be used.

Aim:We aim to understand the role of Candida ciferrii (C. ciferrii) as a pathogen for invasive mycosis. Presentation of Cases: We report six cases of patients with invasive disease due to C. ciferrii from a tertiary care centre of North India in one year. Among the six cases, two cases are of candidemia, three from lower respiratory samples and one from drainage fluid. Discussion: Fungal infections especially candidiasis may occur in immunocompromised patients or in patients with associated co-morbidities. Candidiasis increases both the morbidity and mortality. C. ciferrii has been rarely reported as cause of human infection. It may not be the primary pathogen but has the potential to exacerbate the existing pathology. Conclusion:Rare and unusual pathogens should not be ignored. They should be reviewed in accordance with the patient's clinical manifestations and treated promptly to improve the prognosis of patient in appropriate clinical conditions.