Study shows that software developers spend about 19% of their time looking for information in the web during software development and maintenance. Traditional web search forces them to leave the working environment (e.g., IDE) and look for information in the web browser. It also does not consider the context of the problems that the developers search solutions for. The frequent switching between web browser and the IDE is both time-consuming and distracting, and the keyword-based traditional web search often does not help much in problem solving. In this paper, we propose an Eclipse IDE-based web search solution that exploits the APIs provided by three popular web search engines-Google, Yahoo, Bing and a popular programming Q & A site, StackOverflow, and captures the content-relevance, contextrelevance, popularity and search engine confidence of each candidate result against the encountered programming problems. Experiments with 75 programming errors and exceptions using the proposed approach show that inclusion of different types of contextual information associated with a given exception can enhance the recommendation accuracy of a given exception. Experiments both with two existing approaches and existing web search engines confirm that our approach can perform better than them in terms of recall, mean precision and other performance measures with little computational cost.

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Ovarian endometrioid adenocarcinomas (OEAs) frequently exhibit constitutive activation of canonical WNT signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the b-catenin protein. In previous work, we used microarray-based methods to compare gene expression in OEAs with and without dysregulated b-catenin as a strategy for identifying novel b-catenin/TCF target genes with important roles in ovarian cancer pathogenesis. Among the genes highlighted by the microarray studies was MSX2, which encodes a homeobox transcription factor. We found MSX2 expression was markedly increased in primary human and murine OEAs with dysregulated b-catenin compared with OEAs with intact b-catenin regulation. WNT pathway activation by WNT3a ligand or GSK3b inhibitor treatment potently induced MSX2 and ectopic expression of a dominant negative form of TCF4 inhibited MSX2 expression in ovarian cancer cells. Chromatin immunoprecipitation studies demonstrated that b-catenin/ TCF directly regulates MSX2 expression via binding to TCF binding elements in multiple regions of the MSX2 gene. Notably, ectopic MSX2 expression was found to promote neoplastic transformation of the rodent RK3E model epithelial cell line and to enhance the invasiveness of immortalized human ovarian epithelial cells in vitro and ovarian carcinoma cells in vivo. Inhibition of endogenous MSX2 expression in ovarian endometrioid cancer cells carrying a b-catenin mutation using shRNA approaches inhibited neoplastic properties of the cells in vitro and in vivo. Expression of MSX2 in selected ovarian carcinoma cells induced changes suggestive of epithelial-mesenchymal transition (EMT), but based on analysis of ovarian cell lines and primary tumor tissues, effects of MSX2 on EMT appear to be complex and context-dependent. Our findings indicate MSX2 is a direct downstream transcriptional target of b-catenin/TCF and has a key contributing role in the cancer phenotype of OEAs carrying WNT/b-catenin pathway defects.

This synthesis accomplishes for PSDs what has already been achieved for thiazide-type diuretics and other antihypertensives and can guide the application of these underutilized medicines.

Objectives: To assess the iron status of women using oral contraceptive pill (OCP) and compare this status with that of women of non-OCP users. Methods: This prospective cross-sectional comparative study was done in Dhaka Medical College from January 2006 to December 2006. Total 61 apparently healthy women of low socioeconomic class, age ranged 20-40 years were selected from different areas of Dhaka city. Of them 41 women were OCP users (Study group) and 20 women were non-OCP users (for comparison). OCP users again subdivided into subgroups according to duration of OCP use. Serum ferritin and haemoglobin level were taken as parameters of iron status in both groups. Statistical analysis was done by the SPSS 12.0 programme. Results: The mean (±SD) of serum ferritin level were 59.45±24.79ng/ml and 77.36±35.16 ng/ml in non-OCP & OCP users respectively. The difference of mean (±SD) of serum ferritin levels were significant (p:<0.05) between two groups. The mean (±SD) of haemoglobin levels were 11.54±0.76gm/dl and 12.04±0.79gm/dl in non-OCP user and OCP users respectively. The difference of mean (±SD) were significant (p:<0.05) between two groups. Levels of serum ferritin & haemoglobin were 19ng/ml and 10.95gm/dl respectively in women using OCP for 1 year. But their levels became 144 ng/ml and 13.95gm/dl respectively in women using OCP for 12 years. Conclusion: This study suggests that OCP use raises serum ferritin and haemoglobin levels and thus has beneficial effects on iron status of the body. http://dx.doi.org/10.3329/bjpp.v26i1-2.19963 Bangladesh J Physiol Pharmacol 2010; 26(1&2) : 25-29