The involvement of AP-1 and NF-B transcription factors in cytokine-mediated induction of human inducible nitric oxide synthase (hiNOS) promoter activity was examined. Luciferase reporter plasmids, containing mutations in AP-1 and NF-B sites, in a hiNOS promoter extending from ؊8.3 kilobase pairs (kb) to ؉168, were transiently expressed in A549 cells, and promoter activity was determined after treatment with a cytokine mixture (
There are characteristic abdominal findings in patients with LAM that, in conjunction with the classic thin-section CT finding of pulmonary cysts, are useful in establishing this diagnosis.
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