Earthquakes are the most frequently occurring natural disaster around the world and it is associated with a large outpouring of humanitarian assistance from the world. Existing models for humanitarian non-governmental organizations (NGO) focus on a variety of preparation and response decisions for aid distribution, but tend not to discuss medical rescue teams responding to international disasters and where they would fit into. Aim The aim of this study was to explore the preparedness of South African Non-Governmental Organisation relief teams for international earthquake response. The ultimate aim was to develop a framework for SA NGO teams responding to international earthquake disasters. Methods This qualitative study made use of a range of data collection tools including documentary sources and interviews, so that it could illuminate the study from all sides and to ensure all relevant data from people and organisations that span the globe could be collected. Conclusion and recommendations The result of the study was a conceptual map of the study recommendations which can be used in the development of a framework for improving South African NGO relief teams‟ response efficiency and effectiveness to international earthquake disasters. The research concludes with a series of recommendations which include: assigning the teams under a leading international academic and operational body and to identify qualified, well prepared and professional personnel on a database for rapid deployment.