As eries of stable phosphonium salts have been synthesized via an ovel four-component reaction of an arene nucleophile,2 -heteroatom substituted aryl aldehyde,a nd phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of avariety of bisheteroarenes,p roviding an efficient alternative method to the classical cross-coupling strategies.Scheme 2. Proposed retrosynthetic approach for the synthesis of bisheteroarenes.

AB u 3 P-mediated cyclization reaction of 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones though electrophilic addition of acyl chlorides towards the synthesis of highly functionalizedf uro[3,2-c]coumarins bearing ap hosphorus ylide moiety is described. These unprecedented cyclization reaction proceeds under mild reaction conditions within short reaction times (1 min to 1h), and can be further applied in the synthesis of alkenyl-substituted furo [3,2-c]coumarins by the treatment with carbonyl electrophiles under basic conditions.

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