Osteoporosis is a prevalent bone disease of the aging population, which is characterized by a decrease in bone mass because of the imbalance of bone metabolism. Although the prevention and treatment of osteoporosis have been explored by different researchers, the mechanisms underlying osteoporosis are not clear exactly. N6 methyladenosine (m6A) is a methylated adenosine nucleotide, which functions through its interaction with the proteins called “writers,” “readers” and “erasers.” The epigenetic regulation of m6A has been demonstrated to affect mRNA processing, nuclear export, translation, and splicing. At the cellular level, m6A modification has been known to affect cell proliferation, differentiation, and apoptosis of bone-related cells, such as bone marrow mesenchymal stem cells (BMSC), osteoblasts, and osteoclasts by regulating the expression of ALP, Runx2, Osterix, VEGF, and other related genes. Furthermore, PTH/Pth1r, PI3K‐Akt, Wnt/β‐Catenin, and other signaling pathways, which play important roles in the regulation of bone homeostasis, are also regulated by m6A. Thus, m6A modification may provide a new approach for osteoporosis treatment. The key roles of m6A modification in the regulation of bone health and osteoporosis are reviewed here in this article.

BackgroundThis study was designed to investigate the global emerging trends of physical activity therapy for diabetes based on a bibliometric analysis of the publications.MethodsPublication papers from 2011 to 2020 were retrieved from the database of “Web of Science Core Collection” with the topic search. A number of papers, citations, authors, countries, institutions, and references were extracted. CiteSpace was used to analyze co-citation on authors, collaborations between countries and institutions, and detect the emerging trends of burst keywords and references.ResultsA total of 2651 publications were recruited in this study and showed an upward trend of annual publications. Diabetes obesity & metabolism (journal), the United States (country), Harvard University (institution), and Kaku K (author) published the most papers in this research field. “Impaired glucose tolerance” (2011–2012) was the highest strength burst keyword, while “cardiovascular outcome” (2017–2020) was the most burst keyword in the last 5 years. Moreover, “Standards of medical care in diabetes – 2014” was the strongest burst reference.Conclusion“Physical activity therapy for diabetes” has been accepted remarkably over the last 10 years. The keywords of “impaired glucose tolerance,” “Cardiovascular outcome,” “improves glycemic control,” “Self-management,” and exercise type including “Aerobic exercise, muscle strength” may be the latest research frontiers.

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