Traditional oral dosage forms prone to first pass metabolism and degradation due to enzymes but mucoadhesive films able to bypass first pass metabolism and related degradation. It also offers more patient compliance without risk of chocking in case of paediatric and geriatric patients. Present review has summarised basics of mucoadhesion, composition, method of preparation, characterisation parameters, advantages and disadvantages of buccal mucoadhesive films.

Nebivolol is a third-generation beta-a drenoceptor antagonist. It differs from other beta-a drenoceptor an tagonists as it combines highly selective beta (1)-adrenoceptor antagonist properties with nitric oxide-mediated vasodilator actions and beneficial effects on endothelial function. But this very useful drug use is limited due to challenge of poor water solubility (0.0403 mg/ml). Present study deals with enhancement of solubility of Nebivolol by micro emulsion technique. Various oils, surfactants, and co-surfactants were used to check solubility of Nebivolol. Pseudoternary phase diagrams were constructed using various combinations of ingredients i.e. oil: surfactant: co-surfactant. Micro emulsion batches were prepared by phase titration method. Developed micro emulsion was evaluated for various physicochemical, stability parameters, in-vitro and ex-vivo parameters. Results showed stable micro emulsion form of Nebivolol improved solubility.