Aim: The purpose of this study was to determine the potential of Schrebera Swietenioides alcohol leaf extract in cream composition in the expression of immunoglobulin CD68 (macrophage) during the wound healing process in the inflammatory stage of mice skin. Materials and Methods: Amount of 12 two-months-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. The mice were allotted into four groups of each, entire surface of each group wound covered by base cream control, sulfadiazine 0.1% cream, alcoholic leaves extract of Schrebera Swietenioides cream 10% and, 15%, respectively. All experiments were performed twice a day for 3 days. The wound healing was assayed in stained histological sections in immunohistochemical of the wounds. CD68 expression was investigated under a microscope. Amount of 12-month-old male mice between 30 and 40 g was used. For surgical procedures, a 2.0 cm skin lesion was also performed under the skin on the vertebrae surrounding each animal. Treatment was performed under local anesthetic with procaine cream. Rats were assigned to four groups each, the entire surface of each group of lesions covered by control cream, 0.1% sulfadiazine cream, alcohol leaf from Schrebera Swietenioides cream respectively at 10% and at 15%. All tests were performed twice a day for 3 days. The lesions were analyzed in sections of tissue with staining of wound immunochemistry. The expression of CD68 was studied under a microscope. Results: The results showed that the cream from the 10% and 15% alcoholic leaves extract of Schrebera Swietenioides revealed moderate immune reaction to CD68 on wound healing. Conclusion: We concluded that the alcoholic leaves extract cream of Schrebera Swietenioides possesses anti-inflammatory activity in wound healing process of mice skin.