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Objectives:To investigate the effect of a nonselective β-blocker (propranolol) and cardioselective β-blocker (metoprolol) on wound healing in rats using incision and excision wound models and to compare the effect of these drugs on wound healing.Materials and Methods:Propranolol and metoprolol were given orally. Sprague Dawley rats of either sex were used. Incision and excision wound models were used to evaluate the wound-healing activity. Effects of metoprolol and propranolol on tensile strength, period of epithelialization, and hydroxyproline content were observed. Histological analysis was done to see collagen deposition and inflammatory infiltrate.Statistical Analysis Used:The data was subjected to analysis of variance (ANOVA) followed by Scheffe's test. P < 0.05 was considered to be statistically significant. Statistical analysis was done using SPSS software version 15.0.Results:Administration of propranolol or metoprolol was shown to decrease tensile strength, delay wound contraction and re-epithelialization, increase inflammatory infiltrate, and reduce collagen density and hydroxyproline levels.Conclusions:The results suggest that nonselective and cardioselective β-blockers delay wound healing and these effects are mediated by β1-receptors.

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Objective: Sexual dysfunctions are increasing day by day. Various formulations are available for the treatment of same. There has been psychological mind-set among Indian patients to have powdered medicines for the sexual dysfunction management. The aim of this study was to analyze the preferred formulation by the patients for the treatment sexual dysfunction. Methods: A cross-sectional and observational study was undertaken from January 2018–January 2019 in psychiatry OPD of a tertiary care teaching institute after approval from the Institutional Ethics Committee. A semi-structured questionnaire was made collecting information on demographic details and preferred pharmaceutical formulations for the treatment of sexual dysfunctions. Results: Out of 164 participants who were analyzed, the most common age group having sexual dysfunctions was found to be 21–30 years (44%). Patients preferred Ayurvedic form of treatment (38.41%) over Allopathic (23.17%). Patients were in favor of SOS medications (51.83%) than day or night doses. Majority of the patients wanted drugs in tablet form (67.07%), in monthly doses (43.9%), of white color (39.02%), along with water (54.88%) and at <Rs.100 per strip (67.07%). Conclusions: Majority of the patients prefer Ayurvedic form of treatment and SOS, on monthly basis, white colored tablets, taken with water at affordable prices. These factors need to be kept in mind while formulating new drugs and guidelines to ensure better compliance.