Tendon rupture related to trauma and corticosteroid injection, in and about tendon insertion sites, is well documented in the literature. Rupture of tendon after fluoroquinolone therapy has been identified in the recent past. Both short- and long-term courses of antibiotic treatment with fluoroquinolone may precipitate alteration in tendon matrix leading to tendinopathy with subsequent rupture. The pathogenesis of tendon rupture secondary to fluoroquinolone therapy is presented.

Pathology, part of the basic science of medicine and nursing, is an understanding of how cellular mechanisms and organ systems function conjointly in the physical body. An awareness of the biomechanics and pathophysiology related to a particular mechanism of injury (MOI) provides a more appreciative sense of how tissues become damaged. Cognizance of the variables and risk factors involved in MOI specific to anatomic structures not only helps the Health Care Provider (HCP) decide which treatment options are necessary, but knowing risk factors helps in preventive tactics, counseling an athlete for optimal training, and rehabilitation of the injured athlete. This article discusses the pathophysiology related to anterior cruciate ligament (ACL) injury, one of the most common and costly ligamentous knee injuries. The differentiation between contact versus noncontact mechanisms and risk factors plaguing women athletes will be listed.

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Systemic lupus erythematosus is an autoimmune disease that causes inflammation in the tissues of the brain, endothelial cells, gastrointestinal/genitourinary (GI/GU), joints, kidneys, muscles, and skin. Lupus comprises a range of multisystem disorders involving the deposition of aberrant immune complexes into tissues. Inflammation occurs as a result of autoantibodies attacking organ systems. The pathogenesis of systemic lupus erythematosus is presented.

Dupuytren's disease is a nonmalignant fibroproliferative disease that causes progressive and permanent contracture of the palmar fascia with subsequent flexion contracture of the digits. Although the exact etiopathology in the development of Dupuytren's disease is unknown, certain familial, racial, and physiologic factors have been determined. The latest prospective pathogenesis of Dupuytren's disease are presented.