The high prevalence of abnormal pattern reversal visual evoked potentials to a robust stimulus suggests that visual pathway dysfunction, as measured electrophysiologically, can affect a majority of patients with craniosynostosis. This study indicates that a baseline evaluation of all children with craniosynostosis at their first presentation is essential if subsequent electrophysiologic visual pathway monitoring is to take place.

PurposePattern onset VEPs do not always show distinct C1–C2–C3 peaks and troughs. Our purpose was to study changes in pattern onset VEP with age to determine when the illustrated ISCEV standard onset VEP waveform can be reliably recorded.MethodsWe recorded pattern onset VEPs from an Oz electrode referred to mid-frontal electrode according to ISCEV standards by presenting checks of 60′ and 15′ side length in a 15° field. Twenty-four adults aged 20–63 years participated. Amplitudes and latencies were collated. Pattern onset adult VEP shapes were compared to the waveform published in the ISCEV VEP standard and to paediatric pattern onset VEP waveforms recorded from 16 infants aged 7 months.ResultsThe shape of the pattern onset VEP changed gradually with age. The C1–C2–C3 morphology of the ISCEV standard pattern onset VEP becomes apparent consistently after 40 years to 60′ check stimulation. As age increases a negative trough, C2 is more frequently seen; however, the broad positive peak which characterises infant onset VEPs may still be recorded at 20 years. The group median measurements of onset VEPs to 60′ were C1 7 µV@ 88 ms (range 67–110 ms), C2 9 µV@109 ms (range 89–158 ms) and C3 13 µV@121–246 ms. To smaller 15′ checks, peak latencies were earlier and C2 became more obvious. The group median measures of onset VEPs to 15′ were C1 2 µV@69 ms (55–108 ms), C2 10 µV@90 ms (77–145 ms) and C3 14 µV@122 ms (99–200 ms).ConclusionThe ISCEV standard onset VEP best describes the waveform configuration and latency of the onset VEP produced by 60′ checks in adults of more than 40 years of age. The onset VEP waveform produced by 15′ checks is distinguished by more prominent negative C2 and earlier C1 and C2 latencies.

Antibody (Ab) responses to polysaccharides (PS), such as