15, 30, 45, 60, 90, 120 mins and 6, 12 and 24

Laparoscopic cholecystectomy is itself a lesser painful procedure. 1 but the various after-effects of pain such as difficulty in breathing and coughing, difficulty in moving around and various psychological and behavioural problems along with decreased secretion of Anti-Diuretic Hormone make good postoperative analgesia necessary. The various opioids, which are used for analgesia have various side effects like respiratory depression and also they increase the action of inflammatory mediators. AIMS AND OBJECTIVESThe main aim of our study was, 1. To relieve the patients from postoperative pain and its adverse effects. 2. To decrease the amount of opioids administered and hence relieve from its side effects. 2 3. To study the haemodynamic changes occurring intraoperatively.METHODOLOGY 50 patients were taken in L group and another 50 patients were taken in NS group. All patients were of ASA grade I and II; 0.25% inj. Levobupivacaine was administered to L group patients and only normal saline administered to patients of NS group. STATISTICAL ANALYSISData analysis was performed using SPSS 20 (IBM SPSS Statistics) for windows. VAS score was compared between two groups by repeated measure of analysis of variance. P value <0.05 was considered statistically significant. RESULT AND CONCLUSIONPatients in L group showed better postoperative analgesia and better protection from nausea and vomiting.