Pharmacovigilance plays a consequential role in the surveillance of adverse drug reactions, which is provoked by the drugs used to cure diseases. Adverse drug reactions (ADRs) produce detrimental or undesirable effects to the body after administration of drugs. It has been reported that the number of patients dying because of contrary effects of drugs per year increased upto 2.6-fold. Moreover, rates of hospitalization of patients are increasing owing to adverse effects of drugs. Thus, it becomes challengeable for physician, health care providers, WHO and pharmaceutical industries to resolve the associated problem of ADRs. During the clinical trial of a novel drug, it is prominent to explore the dependability of drug. In this review, we documented the details required to identify the ADRs in patients along with reported banned drugs.

Curcuma caesia is commonly known as kali haldi and it belongs to the family Zingiberaceae.  Black turmeric is an uncommon endemic as well as ethno medicinally important of South East Asia. This herb is available throughout north-east, central India, Papi Hills of East Godavari, West Godavari, and Andhra Pradesh. In the traditional system of medicine, fresh and dried rhizomes of Curcuma caesia are used in treating leucoderma, asthma, tumours, piles, bronchitis, bruises etc. Curcuma caesia has scientifically studied for various therapeutical activities like antioxidant, antibacterial, antipyretic, larvicidal, insecticidal, antimicrobial, wound healing and anti-hyperglycaemic. The present review is an effort to give a detailed survey of the literature on its, phytochemistry, traditional uses and therapeutical studies.

Diabetes mellitus is a global metabolic epidemic affecting essential biochemical activities in almost every age group. Diabetes mellitus is a group of metabolic diseases characterized by high blood glucose level. When the body failed to produce sufficient insulin or is not able to insulin effectively or both leading to diabetes. Presently herbal drugs are widely used for the treatment of diabetes in worldwide. India has a long list of native medicinal plants with confirmed blood sugar lowering property. Some of these have proved remarkable for cure of diabetes and its complications. In this paper an attempt has been made to give an overview of certain Indian plants with their phytoconstituents and mechanism of action which have been studied for their antidiabetic activity.

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