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Present study involves the synthesis, characterization, antimalarial and anticancer activities of some novel substituted amino analogues of 1,4-naphthoquinone. The chloro group present in the key starting materials like 2,3-dichloro-1,4-naphthoquinone (1) and 2-chloro-3-[trans-4-(4-chlorophenyl)- cyclohexyl]-1,4-naphthoquinone (2) was replaced by substituted amines. These analogues were isolated, purified and screened for antimalarial and anticancer activities. A few of the novel compounds were found to possess substantial biological activity and are reasonably potent.

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