A smart city is a trending concept describing a new generation of cities operated intelligently with minimal human interaction. It promotes energy sustainability, minimal environmental impact, and better governance. In transportation, the highway infrastructure will enhance the driver’s safety by remotely monitoring traffic, road conditions, and potential hazardous incidents, such as accidents, floods, or snow storms. In addition, it facilitates the integration of future cutting-edge technologies, such as self-driving vehicles. This paper presents a general introduction to a smart monitoring system for automated real-time road condition inspection. The proposed solution includes hardware devices/nodes and software applications for data processing: road condition inspection using hybrid algorithms based on digital signal processing and artificial intelligence technologies. The proposed system has an interactive web interface for real-time data sharing and the monitoring, visualization, and management of inspection reports which can improve the maintenance process assistance.