Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synthesis of the building blocks is presented along with representative derivatization. Preliminary studies reveal that the [2]-ladderanes offer similar metabolic and physicochemical properties thus establishing this class of molecules as interesting motifs.

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Fibromas are benign tumors that are composed of fibrous connective tissue. Fibroepithelial polyp (FEP) is a histological variant of fibroma that causes esthetic and functional problems. They may arise anywhere in the oral cavity, but are more commonly seen in the gingiva, tongue, and lip. Generally small and painless, they rarely continue to grow and might resemble other malignant lesions. This article reports an unusual case of a huge intraoral FEP that presented as a cauliflower-shaped lesion mimicking other neoplastic lesions. Laser excision was carried out following which histopathological examination revealed it as an inflamed FEP with ulceration. How to cite this article Paul S, Pudukulangara A, Kulal R, Sambashivaiah S. Report of an unusually Huge Fibroepithelial Polypmanagedwith Diode Laser. JHealth Sci Res 2015;6(2):52-55.

Aims The treatment of gingival inflammation is associated with improved glycemic control in diabetic patients. The aim of this study was to test the short-term effects of professional oral hygiene procedures on plasma glucose levels in systemically healthy individuals with periodontal diseases. Materials and methods Forty-five systemically healthy individuals visiting the RajaRajeswari Dental College & Hospital were randomly allocated into three groups, group I (gingivitis), group II (periodontitis), and group III (healthy control). The subjects of groups I and II were treated by scaling and root planning whereas the healthy control group did not receive any treatment. The plasma glucose levels were estimated at baseline for all the three groups. Plasma glucose levels were again assessed immediately following the oral hygiene procedures and at 1 week recall visit for groups I and II. Results All 45 patients completed the study. There were no dropouts. There was no statistically significant change in random blood sugar (RBS) level in group I (gingivitis) from baseline to postoperative whereas there was a statistically significant reduction in the mean RBS levels from postoperative to 1 week. In group II (periodontitis), there was a significant reduction in the mean values of RBS from baseline to postoperative and baseline to 1 week. Conclusion This short-term study showed that professional oral hygiene procedures are effective in improving the glycemic status of systemically healthy patients with periodontal diseases. How to cite this article Kulal R, Paul S, Sambhashivaiah S, Shivanand S. Influence of Professional Oral Hygiene Procedures on Plasma Glucose Levels of systemically Healthy Individuals: A Short-term Study. J Health Sci Res 2015;6(2):29-32.