Seventy-five single-rooted teeth diagnosed with asymptomatic necrosis and apical periodontitis were randomly assigned to 3 experimental groups (n=25), according to the root canal sealer:  MTA Fillapex, CPM Sealer, and AH Plus. Calcium hydroxide was employed as intracanal dressing throughout used during   endodontic procedure. Classify each patient's discomfort as none, slight, moderate, or severe. Pain was rated between 1 and 4 after 24 hours, 48 hours, and 7 days. Also, analgesic use was monitored. The chi-square test contrasted postoperative pain and painkiller use. The ordinal (linear) chi-square test measured pain following therapy. There were no differences between groups in postoperative pain frequency, severity, or analgesic intake (p>0.05). After 7 days, no pain. Postoperative discomfort and the requirement for analgesics were the same for AH Plus, CPM Sealer, and MTA Fillapex. Aim of study: This clinical study was created to evaluate the frequency and intensity of pain with analgesic intake following root canal therapy utilizing various root canal sealers (MTA Fillapex, CPM Sealer, AH Plus).