Livestock is an important sub-sector of agriculture that plays a key role in economy of a country by contributing to GDP (Gross Domestic Product) and in total export. Pakistan is the 5 th largest milk producer in the world with a total milk production of about 46.44 billion liters per anum. Almost 68% milk is produced by buffalo and 27% by cow. Pesticides used in agriculture sector may transfer to animal bodies through feed and fodder. A pesticide found in water is another source of residues in milk through drinking water. External control of parasites on animal body, insect control in cattle yard and sheds are direct sources of pesticides exposure for dairy animals. Due to its nutritional and supplementary value, milk is being consumed by people of different age groups therefore, issue of pesticide residues attain the immediate attention of researcher. Pesticide residues levels in raw dairy milk are discussed here in few selected developing and developed countries. It is concluded that human health is associated with exposure to organo phosphorus (OPPs), organo chlorine pesticide (OCPs), pyrethroids and carbamate (CB) pesticides via milk or milk products and this issue deserve more attention. Different classes of pesticides OPPs, OCPs, pyrethroids and CBs etc. were reported in raw dairy milk in different countries and also in Pakistan. The results of this review demonstrate the need to establish pesticide residue monitoring programs for milk analysis for human consumption to improve food safety and decrease exposure risks to consumers.

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European Union Reference Laboratory method for Fruits and Vegetable (EURL-FV-2010-M1) for the quanti cation of pesticide residues was veri ed for the determination of multiple pesticides residues in okra. The targeted pesticides were extracted using acetonitrile with citrate buffer salts followed by cleanup with primary secondary amine (PSA) and analyzed on LC-MS/MS. The recoveries for all the targeted pesticides were within an acceptable range of 70.1 -116.6% and precision in terms of RSD was 0.3 -18.1%, respectively. The limit of quanti cation ranged from 0.002 mg/kg for carbofuran to 0.5 mg/kg for αcypermethrin. The status of pesticide residues in okra (n= 21) available to consumers in the main markets of Pakistan has been determined by using this veri ed method. Sixty-two percent of the tested samples were contaminated out of which three samples were non-compliant with European Union Maximum residue limits (EU-MRL). The pesticides violating the EU-MRL were bifenthrin, thiamethoxam, and triazophos. For all the detected pesticides, estimated daily intake (EDI) ranged between 7.39×10 −6 and 1.78×10 −4 mg/kg of body weight while the values of Health Index (HI) uctuated between 8.9×10 −5 and 1.8×10 −2 .Although, residues of some pesticides were reported to be non-compliant with EU-MRLs, yet the risk posed by these pesticides to human health was insigni cant.

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