Background In Yemen; initial surveillance of COVID-19 focused primarily on patients with symptoms or severe disease and The full spectrum of the disease are not clear. To the best of our knowledge, this is the first seroprevalence study done in Yemen. Methods It is a one-time cross-sectional investigation among 2000 participants from all age groups from four districts in Aden at southern Yemen. A multi-stage sampling method used. Data collected by using a well-structured questionnaire and blood sample were collected. Healgen COVID-19 IgG/IgM Rapid diagnostic Test (RDT) Cassette was used in all participants. All positive RDTs and 14% of the negative RDTs underwent ELISA test (WANTAI SARS-CoV-2 Ab Elisa Kit) Results A 549 out of 2001 participants were RDT positive and proved by ELISA giving the prevalence of COVID-19 infection to 27•4% and specifically the prevalence of IgG was 25%. The prevalence of asymptomatic COVID-19 infection in all the study group was 7•9%. The highest prevalence was observed in Al-Mansurah district (33•4%). Regarding socio-demographic factors females, housewives and history of contact a COVID-19 patients have significant higher prevalence rates (32%, 31% and 39% respectively). Conclusion high prevalence of SARS-CoV-2 antibodies was reported. Household contacts are the main factors for transmission.

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