Comprehensive community initiatives (CCIs) coordinate social and structural change across multiple community sectors and represent promising approaches to complex social problems. Nowhere is this more relevant than for Indigenous children and families. However, strategies to evaluate initiatives to enhance Indigenous well-being must be meaningful to Indigenous communities. A review of literature regarding evaluation of CCIs identified various principles, case studies, methodologies, and methods grounded in Western ways of knowing and approaches to research. Research that engages with Indigenous led comprehensive community initiatives is needed to enhance evaluation practices for CCIs that enables resurgence of Indigenous traditions and worldviews.