In this paper, a novel memristor-based multi-scroll hyperchaotic system is proposed. Based on a voltage-controlled memristor and a modulating sine nonlinear function, a novel method is proposed to generate the multi-scroll hyperchaotic attractors. First, a multi-scroll chaotic system is constructed from a three-dimensional chaotic system by designing a modulating sine nonlinear function. Then, a voltage-controlled memristor is introduced into the above-designed multi-scroll chaotic system. Thus, a memristor-based multi-scroll hyperchaotic system is generated, and this hyperchaotic system can produce various coexisting hyperchaotic attractors with different topological structures. Moreover, different number of scrolls and different topological attractors can be obtained by varying the initial conditions of this system without changing the system parameters. The Lyapunov exponents, bifurcation diagrams and basins of attraction are given to analyze the dynamical characteristics of the multi-scroll hyperchaotic system. Besides, the FPGA-based digital implementation of the memristor-based multi-scroll hyperchaotic system is carried out. The experimental results of the FPGA-based digital circuit are displayed on the oscilloscope.