This study demonstrates that in vivo mAb modifications are not fully represented by in vitro PBS or plasma incubation. The differences in modifications and their rates reflect the dissimilarities of matrices and the impact of enzymes. These observations provide valuable evidence and knowledge in evaluating the criticality of modifications that occur naturally in vivo that might impact formulation design, therapeutic outcome, and critical quality attribute assessments for therapeutic mAb manufacturing and quality control.

5G has brought a huge increase in data, and the number of nodes and types of messages are becoming more and more complex. The Internet of things has become a large and complex network. More and more devices can be used as nodes in opportunistic social networks. The attitude of nodes to messages is different and changeable. However, in the previous opportunistic network algorithm and mass data transmission environment, due to the lack of effective information selection and management means, it was easy to lead to transmission delay and high consumption. Therefore, we propose Effective Data Selection and Management (EDSM). EDSM uses the current state of the node as the basis for forwarding messages. When the cache space is insufficient, EDSM will perform cache replacement based on the message cache value and delete the information with the lowest cache value. Simulation results show that the algorithm has good performance in terms of delivery rate and latency.

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The evaluation of the rural infrastructure construction is the premise and foundation of its decision-making. In order to promote the integration and common prosperity of urban and rural development, gradually narrowing the gap between urban and rural areas, and improve the efficiency of the new socialist rural infrastructure construction, this paper analyzed the characteristics of rural infrastructure construction of Shaanxi province based on a large number of visiting to research and classified the rural infrastructure construction of Shaanxi. In the end of the paper, it proposed the Gray-AHP evaluation methods of rural infrastructure construction ,which will play a guiding role for rural infrastructure construction of Shaanxi province in future.