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Abbreviations: FDR, false discovery rate; miRNA, microRNA; NAFLD, nonalcoholic fatty liver disease; qRT-PCR, quantitative reverse transcription polymerase chain reaction; SAM, signifi cance analysis of microarray; STZ, streptozotocin.

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Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, and its hepatoprotective effect was accompanied by activation of the PI3K/Akt pathway and mediated by regulation of the composition and metabolic function of the intestinal microbiota. This finding suggested that the microbial community is a non-negligible impact on drug metabolism and probiotic administration could be a potential therapy for drug-induced liver injury.

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