Objective To understand the bacterial profile and antibiotic resistance patterns in diabetic foot infection (DFI) in different Wagner's grades, IDSA/IWGDF grades, and different ulcer types in Guangzhou, in order to provide more detailed suggestion to the clinician about the empirical antibiotic choice. Methods 207 bacteria were collected from 117 DFIs in Sun Yat-sen Memorial Hospital from Jan.1, 2010, to Dec.31, 2015. The clinical data and microbial information were analyzed. Results The proportion of Gram-negative bacteria (GNB) was higher than Gram-positive bacteria (GPB) (54.1% versus 45.9%), in which Enterobacteriaceae (73.2%) and Staphylococcus (65.2%) were predominant, respectively. With an increasing of Wagner's grades and IDSA/IWGDF grades, the proportion of GNB bacterial infection, especially Pseudomonas, was increased. Neuro-ischemic ulcer (N-IFU) was more susceptible to GNB infection. Furthermore, with the aggravation of the wound and infection, the antibiotic resistance rates were obviously increased. GPB isolated in ischemic foot ulcer (IFU) showed more resistance than the N-IFU, while GNB isolates were on the opposite. Conclusions Different bacterial profiles and antibiotic sensitivity were found in different DFU grades and types. Clinician should try to stay updated in antibiotic resistance pattern of common pathogens in their area. This paper provided them the detailed information in this region.
Chang'e‐4 (CE‐4) achieved the first farside landing in Von Kármán crater. In the landing site, linear features have been identified previously from SLDEM and considered to be ejecta from the neighboring Finsen crater. The 5 cm grid spacing digital elevation model of the landing site, generated from the rover's panoramic images, provides more details of the rugged terrain. We further interpret the superimposition of NE‐SW ejecta from Finsen crater on the underlying SE‐NW dome‐like surface relief from Alder crater. The landing site is ~70 m higher than the mare basalts within Von Kármán crater. Numerical simulations predict ~30 and ~35 m ejecta deposited at the landing site from Finsen and Alder craters, respectively. The good agreement between the digital elevation model data and ejecta predicted thickness reveals the topographic evolution of Von Kármán crater, indicating that the rover‐measured material is excavated from Finsen crater with possible contributions from Alder crater.
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