Background Permanent epicardial pacing is an effective treatment for pediatric patients especially for those with low body weight, small body size or complex cardiac structures. This study aimed to investigate the follow-up results and identify the associated risk factors of epicardial pacing in children. Method Pediatric patients who successfully received permanent epicardial pacing treatment at Guangdong Provincial People's Hospital from March 2005 to March 2021 were included in this study. The surgical data, echocardiographic examination parameters, incidence of reoperation, and long-term complications of these patients were recorded. Result A total of 139 patients were enrolled in this study. The median follow-up period was 50 months. Compared to a baseline measurement, there was a significant decrease in the postoperative left ventricular end-diastolic diameters. For patients with left ventricular systolic dysfunction, left ventricular ejection fraction and left ventricular fractional shortening significantly improved after implantation. Thirty-one patients (22.3%) had complications in the follow-up period, and the most common was lead failure (14.4%). The reoperation incidence was 33.8%. Right ventricle pacing is a risk factor associated with reoperation. The five-years survival time of leads and batteries were 84.5% and 83.4%, respectively. Right ventricle pacing was the only risk factor which significantly reduced the lifespan of lead and battery. Conclusion Permanent epicardial pacing therapy is an effective treatment in children in spite of postoperative complications. RV pacing is a significant risk factor for reoperation, and it increases the occurrence of complications and reduces the survival time of the lead and battery.