Measurement of creatinine has many applications. We review the determination of urinary creatinine as a valid index of completeness of 24-h urine collection, the clinical utility of the determination of creatinine clearance ratios, and measurement of the ratio of the clearance of specific analytes, such as amylase, to the ratio of clearance of creatinine. The chemistry and variables that affect the Jaffé reaction are reviewed, and attempts at improvement of specificity are discussed. We also review and assess techniques other than the Jaffé reaction for measurement of creatinine.

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Background The anatomical and physiological characteristics such as neuromotor coordination impairments and craniofacial and structural abnormalities frequently interfere with the acquisition of effective oral‐motor skills which can in turn result in the development of potential feeding problems and swallowing dysfunction. The present study was undertaken with the aim of assessing the feeding and swallowing problems, if any, in children with Down syndrome in the age range of 2–7 years. Methods A questionnaire was formulated and administered on 17 children with Down syndrome (10 females and 7 males) and 47 typically developing children (20 females and 27 males). Results The present study revealed that feeding difficulties were predominantly present in children with Down syndrome. These difficulties were found in all the three phases of swallow and were greatest for solids followed by liquids. They also had issues with physical, functional and emotional aspects of feeding. Further, the children with Down syndrome exhibited poor orosensorimotor abilities which could have lead to the difficulties in feeding. Conclusions The study highlights the importance of including feeding assessment in the evaluation protocol of infants and children with Down syndrome.

The preanalytic phase is an important component of total laboratory quality. A wide range of variables that affect the result for a patient from whom a specimen of blood or body fluid has been collected, including the procedure for collection, handling, and processing before analysis, constitute the preanalytic phase. Physiologic variables, such as lifestyle, age, and sex, and conditions such as pregnancy and menstruation, are some of the preanalytic phase factors. Endogenous variables such as drugs or circulating antibodies might interact with a specific method to yield spurious analytic results. The preanalytic phase variables affect a wide range of laboratory disciplines.