Aim
The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions.
Methods and results
In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-stent technique (two-stent group) or provisional stenting (provisional group). The primary endpoint was the composite of target lesion failure (TLF) at the 1-year follow-up, including cardiac death, target vessel myocardial infarction (TVMI), and clinically driven target lesion revascularization (TLR). The safety endpoint was definite or probable stent thrombosis. At the 1-year follow-up, TLF occurred in 37 (11.4%) and 20 (6.1%) patients in the provisional and two-stent groups, respectively [77.8%: double-kissing crush; hazard ratio (HR) 0.52, 95% confidence interval (CI) 0.30–0.90; P = 0.019], largely driven by increased TVMI (7.1%, HR 0.43, 95% CI 0.20–0.90; P = 0.025) and clinically driven TLR (5.5%, HR 0.43, 95% CI 0.19–1.00; P = 0.049) in the provisional group. At the 1 year after indexed procedures, the incidence of cardiac death was 2.5% in the provisional group, non-significant to 2.1% in the two-stent group (HR 0.86, 95% CI 0.31–2.37; P = 0.772).
Conclusion
For DEFINITION criteria-defined complex coronary bifurcation lesions, the systematic two-stent approach was associated with a significant improvement in clinical outcomes compared with the provisional stenting approach. Further study is urgently warranted to identify the mechanisms contributing to the increased rate of TVMI after provisional stenting.
Study registration
http://www.clinicaltrials.com; Identifier: NCT02284750.
In this paper, we investigate a new rectangular-fed printed open-slot antenna (POSA) with reflector, which has the advantages of improved radiation-pattern properties along with broad-bandwidth characteristics. The measured bandwidth of the proposed POSA with reflector is approximately 47.6% (Ϫ10 dB Ն S 11 ), thus, it can be used for PCS, DCS, and IMT-2000. But the measured bandwidth of the PCSA with reflector is approximately 46% (with VSWR Յ 2.0). The tilt angle at maximum gain is enhanced by using a modified POSA with reflector for practical applications. The radiation pattern null and distortion of the open-slot antenna exhibited better performances than those of the closed-slot antenna. The back-lobe level of the POSA with reflector also presented much better results than the PCSA with reflector. The proposed antenna obtained not only wider bandwidth but also better radiation patterns characteristics than the PCSA with reflector.ABSTRACT: This paper presents an active broadband-transmitting patch antenna, which works in the 1650 -2300-MHz band to provide GSM-1800 and UMTS services. An increase of the reflection bandwidth of the referenced passive antenna has been achieved due to the resistively equalized broadband-amplifying active antenna. An increase in equivalent isotropic radiated power (EIRP) of 11-12 dB compared to the passive antenna, with a ripple lower than Ϯ0.5 dB, has also been achieved.
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