A 49-year-old patient with previously known multivessel disease presented with myocardial infarction and underwent cardiac catheterization, during which he sustained a severe ischemic stroke as a complication of the procedure. This operation involved re-opening the right coronary artery (RCA), mechanical thrombectomy (MT) for the right middle cerebral artery, and recanalization via a radial and femoral approach. After follow-up with rehabilitation. One week later, interventional revascularization of the left anterior descending artery (LAD) and left circumflex (LCx) was performed successfully.