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The new, belonging to the streptothricin-group antibiotics AN-201 I, II and III were found to be produced by a soil actinomycete identified as Streptomyces nojiriensis C-13. The chemical structures and the physical and spectroscopic properties of these compoundsare reported here. On the basis of NMR and fast atom bombardmentmass spectrometry (FAB-MS) spectra the antibiotics were identified as iV^-acetylated derivatives of streptothricins E,DandF.In the course of our screening study for antitumor antibiotics, newstreptothricin antibiotics, named AN-201 I, II and III, were isolated from the culture broth of Streptomyces nojiriensis C-13. Our previous paper1} was concerned with their production by fermentation, isolation and biological activities. They were effective against both Gram-positive and Gram-negative bacteria, and showed in vitro and in vivo antitumor activity. The structures of AN-201I, II and III are determined as the iV^-acetylated derivatives of streptothricins E, D and F (Fig. 1). This report describes the structure elucidation by application of NMRand fast atom bombardment mass spectrometry (FAB-MS).

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