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Introduction. Benzamide can specifically bind to melanoma cells. A 18F-labeled benzamide derivative, [18F]N-(2-diethylaminoethyl)-4-[2-(2-(2-fluoroethoxy) ethoxy)ethoxy]benzamide ([18F]FPBZA), was developed as a promising PET probe for primary and metastatic melanoma. Methods. [18F]FPBZA was synthesized via a one-step radiofluorination in this study. The specific uptake of [18F]FPBZA was studied in B16F0 melanoma cells, A375 amelanotic melanoma cells, and NB-DNJ-pretreated B16F0 melanoma cells. The biological characterization of [18F]FPBZA was performed on mice bearing B16F0 melanoma, A375 amelanotic melanoma, or inflammation lesion. Results. [18F]FPBZA can be prepared efficiently with a yield of 40–50%. The uptake of [18F]FPBZA by B16F0 melanoma cells was significantly higher than those by A375 tumor cells and NB-DNJ-pretreated B16F0 melanoma cells. B16F0 melanoma displayed prominent uptake of [18F]FPBZA at 2 h (7.81 ± 0.82 %ID/g), compared with A375 tumor and inflammation lesion (3.00 ± 0.71 and 1.67 ± 0.56 %ID/g, resp.). [18F]FPBZA microPET scan clearly delineated B16F0 melanoma but not A375 tumor and inflammation lesion. In mice bearing pulmonary metastases, the lung radioactivity reached 4.77 ± 0.36 %ID/g at 2 h (versus 1.16 ± 0.23 %ID/g in normal mice). Conclusions. Our results suggested that [18F]FPBZA PET would provide a promising and specific approach for the detection of primary and metastatic melanoma lesions.

The research discusses sound insulation on some designed types of ventilated soundproof windows which combine with fans and the air lead-in boards. Conclusions are as the following, The result shows that the type of left-inlet and right-outlet could reach 30.4 dB(A) of sound insulation and the type of double-sided duct could reach 30.7 dB(A) of sound insulation. Changing glass thickness of window, 5mm and 10mm, the sound insulation of ventilated soundproof windows show that frequency response are almost the same by comparing three different types. It shows that has no improvement of sound insulation by adding the glass thickness. Discussing the influence of indoor environment due to fan noise. For the type of normal ventilation, the noise is 41.2 dB(A) when the fan set at the middle speed with air lead-in boards. For the type of double-sided duct, the noise is 33.7 dB(A) when the fan set at the middle speed with air lead-in boards. For the type of left-inlet and right-outlet, the noise is 36.4 dB(A) when the fan set at the middle speed with air lead-in boards. Acknowledgment of support to National Science Council, NSC 100-2221-E-244 -019