Adenocarcinoma of the appendix invading the urinary bladder is very rare. We describe such a case in a 42-year-old man and review the relevant literatures. In the present case, although ultrasonography and computed tomography scan revealed a mass in the bladder or in the pelvic and biopsies by cystoscopy showed an adenocarcinoma suspicious for primary of the bladder, its real origin was hard to distinguish. An open exploratory surgery was performed with subsequent resection of appendix and partial bladder. Postoperative histopathological examinations revealed the appendiceal adenocarcinoma infiltrating the bladder wall. The patient refused the right hemicolectomy and received 3 cycles of adjuvant radiotherapy. However, tumor recurrence was found in the bladder 6 months after surgery, and radical cystectomy was eventually performed.

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