Shiho Shimizu scite author profile

A Gram-positive bacterium Lentzea sp. 7887 hydroxylates a cyclosporine derivative FR901459 into AS1837812 (9-hydroxide), which is an important intermediate of candidate drugs that target the hepatitis C virus. We screened a UV-induced mutant, named M-1, which showed about 1.2-fold higher conversion yields, 2-fold higher substrate concentrations (3.69 mM), and 2.5-fold higher yield per unit volume than the wild-type strain.

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Shiho Shimizu

Improvement of FR901379 production by mutant selection and medium optimization

Pilot-scale whole-cell biocatalysis for the hydroxylation of cyclosporine derivative, FR901459, at higher concentrations by Lentzea sp. 7887 using soybean flour as a novel substrate dispersant

Strain selection and scale-up fermentation for FR901379 acylase production by Streptomyces sp. no. 6907

Rapid Evaluation of the Bioremediation of Fuel Oil in Soil by Gas Chromatography–Laser Ionization Time-of-Flight Mass Spectrometry

Strain improvement of Lentzea sp. 7887 for higher yield per unit volume on hydroxylation of cyclosporine derivative FR901459

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