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Background The association of contrast-enhanced MRI (CE-MRI) and the overall survival (OS) of biliary tract cancers (BTC) is ambiguous. Thus, the aim of this study is to evaluate the value of signal enhancement ratio (SER) and its early change in CE-MRI as biomarkers of survival after hepatic arterial infusion chemotherapy (HAIC) in BTC. Results One hundred and two BTC patients treated via HAIC with 3cir-OFF regimen between January 2011 and June 2020 were enrolled in this retrospective study. The median progression-free survival (PFS) and OS were 9.8 months [range 1.5–83.3 months, 95% confidence interval (CI) 7.789–11.811] and 14.2 months (range 1.8–83.3 months, 95% CI: 11.106–17.294), respectively. The cutoff value of SER before HAIC (SER0) was 1.04, and both median PFS and OS in the SER0 ≥ 1.04 group were longer than in the SER0 < 1.04 group (median PFS: 10.5 vs. 8.5 months, p = 0.027; median OS: 23.9 vs. 12.3 months, p < 0.001). The median OS in the ΔSER > 0 group was longer than in the ΔSER < 0 group (17.3 versus 12.8 months, p = 0.029 (ΔSER means the change of SER after two cycles of HAIC). Multivariate analysis showed SER0 (p = 0.029) and HAIC treatment cycle (p = 0.002) were independent predictors of longer survival. Conclusions SER in CE-MRI before HAIC (SER0) is a potential biomarker for the prediction of survival after HAIC in advanced BTC.

were retrospectively collected. Detailed data on surgical volume, procedures, and peri-operative outcomes, stratified by each specialty, were carefully studied and compared with the results from previous years. Progress in education and research were also reported.Results: In 2018, 58 thoracic surgeons, including 23 attending surgeons and 35 clinical fellows and residents, performed 14,054 major thoracic surgeries, including 11,958 pulmonary procedures, 866 esophageal procedures, 957 mediastinal procedures, 45 trachea procedures, and 7 lung transplantations. The total volume increased by 13.9% compared with the previous year. Among them, 88.4% were accomplished via minimally invasive approaches, including both video-assisted thoracoscopic/laparoscopic surgery and robotic surgery. There was a clear trend towards increased use of minimally invasive techniques for more complicated thoracic diseases in each specialty. More importantly, the unplanned reoperation rate, readmission to ICU rate, and 30-day mortality rate were all maintained in an extremely low level, being 0.37%, 0.82% and 0.21%, respectively. Conclusions: Tremendous effort has been engaged in improving Thoracic Surgery service at the Shanghai Chest Hospital. The year 2018 witnessed not only continuous increase in volume but also persistent high quality and safety in patient care. With these accomplishments and focus on more innovations, we will strive to deliver higher level of medical services in the future.