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Background: To construct and evaluate the new Clinical Nutrition Nurse Practice Training Center in Guangdong Province. Methods: Seventy-four specialized nutrition nurses were trained from 2019-2020. Their core abilities and performance of duties were evaluated using the Clinical Nutrition Specialty Nurses Core Competence Self-evaluation Scale. This study adhered to the Revised Standards for Quality Improvement Reporting Excellence (SQUIRE 2.0) guidelines. This study was approved by the Ethics Committee of "The Third Affiliated Hospital of Sun Yat-sen University". Results: The nurses obtained higher results one year after graduation compared with before training. Except for the areas of writing and participation, all training dimension differences were statistically significant (p < 0.05) for working nutritional nurses. Conclusions: The results indicate that the training provided in the Clinical Nutrition Nurse Practice Training Center is effective in improving the quality of specialist nursing as a whole.

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