Cancer mortality
is increasing at an alarming rate across
the globe.
Albeit, many therapeutics are available commercially, they are not
effective and have no cure up to today. Moreover, the knowledge gap
in cancer therapy persists, representing a potential blind spot for
the innovation of effective anticancer therapeutics. This review presents
an update on current advancements in nanopeptide therapeutics. Herein,
a detailed exploration of peptide-functionalized nanoparticles for
the development of nanotherapeutics was carried out. Different approaches
that include self-assembly nanostructures, solid phase peptide synthesis,
ligand exchange, chemical reduction, and conjugation methods for assembling
peptides for functionalizing nanodrugs are also highlighted. An outlook
on biomedical applications is also reviewed. Additionally, a comprehensive
discussion on targeted cancer cell therapy and mechanism of action
are provided. The present review reflects the functional novelty of
nanodrugs to improve stability, accessibility, bioavailability, and
specificity toward cancerous cells. Finally, it summarizes the current
challenges and future perspectives on the formulation of these nanodrugs.
Diabetes mellitus is characterized by altered blood sugar homeostasis. A chronic metabolic disorder affecting millions of people worldwide. Diabetic mortality rates are escalating in developed countries by the clock. Till...
Pesticides are widely used to prevent bug infestation in agricultural crops and to get rid of other pests and disease-carrying creatures including mice, rats, ticks, and mosquitoes from various environment and h In response to this environmental and human health hazard, a dire need for remediation has emerged in the last few decades. Green approaches for the remediation of pesticides can boost sustainable development. A biomimetic approach for degradation of pesticides can have high potential to generate ripples of positive outcomes. Biomimetic catalysts are synthetic chemical molecules which have been inspired by natural processes to mimic their structural and functional properties. This short review concisely focuses on the synthesis of various biomimetic catalysts including metal-based materials, carbon-based materials and others. In this context, recent advances achieved by such biomimetic catalysts for the degradation of pesticides have been covered. It highlights the importance of adopting a biomimetic approach as it provides a green and efficient method for pesticides degradation
Emission of greenhouse gases (GHG) by fossil fuels surged at a fast pace ensuing rise in Earth’s temperature, altogether cause the most dangerous impact, i.e., global warming. Endless efforts are...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.