Background: The effect of levonorgestrel-releasing intrauterine system (LNG IUS) on metabolic parameters like body mass index, body weight, blood pressure, blood sugar, lipid profile and liver function test is still unclear. Objective: To assess the possible metabolic effects of the levonorgestrel intrauterine system on serum lipids, body weight and fasting blood glucose level after a period of six months. Subjects and Methods: A prospective study comprised 50 women attended to the Department of Family Planning in Sadat city Hospital and request intrauterine hormonal contraception during the period from December 2018 to August 2019. Full history, routine, physical examination and special investigations were taking. Results: There were no statistically significant differences between the studied patients regarding Socio-demographic characteristics before and after 6 months follow up. Menstrual change was the most adverse effects among the studied patients (15 cases, 32.61%), followed by spotting in 6 cases (13.04%) then lower abdominal pain in 5 cases (10.87%). While, weight gain recorded the lowest frequent (2.17%). Regarding overall satisfaction with the method, most of the studied patients had very or somewhat satisfied (32 cases, 69.57%) and 14 cases (30.43%) had neutral or somewhat not satisfied. Conclusions: Among the Egyptian the LNG-IUS does not have any adverse effects on metabolic parameters, TGs, LDL and blood sugar levels. Most of the studied patients had very or somewhat satisfied with methods and 30.43% had neutral or somewhat not satisfied.