NAC does not appear to play a role in the treatment of cancer of the oral cavity and pharynx with our PEM regimen. However, the degree of toxicity was limited in our trial and therefore attempts to increase the dosage and/or revise the administration schedule for cancer of the pharynx and T1 to T3 tumor disease appear warranted.

Powder neutron diffraction data have been recorded for LiMnVO,. The crystal structure was determined by Rietveld analysis. The Rietveld refinement confirmed that the compound adopts an orthorhombic spinel-related structure. The framework structure of the compound is comprised of nearly regular, edge-sharing octahedra of MnO,. The lithium and vanadium atoms in LiMnVO, occupy, as partially mixed species, the two kinds of tetrahedral interstitial sites constructed by cubic close-packed oxygen atom arrays; this structural feature is quite similar to those of CrV0, and LiCuVO,. The magnetic susceptibility and the metal-oxygen bond distances estimated from the refined structure of LiMnVO, clearly indicate that the valence states for the transition-metal ions are divalent for manganese ions and pentavalent for vanadium ions.

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