Abstract— We have developed novel liquid‐crystal (LC) materials with a difluoromethyleneoxy CF2O) moiety as the linkage group in order to satisfy the various requirements of active‐matrix liquid‐crystal displays (AMLCDs). We measured the physical properties of the CF2O LC materials. The novel CF2O LC materials have excellent physical properties, that is, high dielectric anisotropy, low viscosity, a broad nematic range, high reliability, etc. It was revealed that several advantages can be obtained by the introduction of CF2O moiety into the LC molecules. The mixture containing CF2O LC materials for various applications indicated a decrease in rotational viscosity of about 15–25% compared with that for conventional LC mixtures. Also, these novel mixtures with CF2O LCM demonstrated a higher voltage‐holding ratio (VHR). It was confirmed that mixtures containing CF2O LC materials have suitable characteristics for various applications, for example, low‐driving‐voltage note‐book PCs, quick response monitors, and transflective applications.