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CREB dysfunction, mediated by PKA and iPLA2 suppression, may be involved in the deteriorated liver regeneration in the cirrhotic rats.

Hybrid liposomes (HLs) composed of l-α-dimyristoylphosphatidylcholine and polyoxyethylene (25) dodecyl ether having 80 nm in diameter were produced. It is noteworthy that the therapeutic effects of HLs along with apoptosis without side effect were obtained using xenograft mice models of human breast cancer in vivo for the first time.