A 68-year-old woman with a 2-month history of nausea and occasional vomiting was referred to the gastroenterologist. The patient complained of vague upper abdominal discomfort that was not influenced by meals. Laboratory findings were normal, and, specifically, no anemia was present (hemoglobin level, 8.4 mmol/L [normal, 7.1-9.9 mmol/L]; hematocrit level, 0.41 [normal, 0.34-0.48]). The patient reported normal bowel movements but mentioned a recent short period of diarrhea. Neither rectal bleeding nor melena was present, and fecal occult blood testing was not performed.A gastroscopy was performed by the gastroenterologist, who noted an extrinsic impression at the greater curvature of the stomach. The pyloric orifice was poorly recognized, and there was suspicion for an intussusception of part of the antrum into the duodenum. Rotation of the proximal part of the duodenum and reduction of the diameter of the duodenal lumen by more than 50% were present as the result of an external mass (Fig 1). The surface of the mass was mostly covered with normal-looking mucosa but became firm and ulcerative more distally. Because of the limited view at gastroscopy, it was difficult to determine whether the duodenal lumen reduction was the result of a submucosal mass or an external invading mass. Several biopsy specimens were obtained from both the normal-appearing mucosa proximal to the narrowed part of the duodenum and the more distal ulcerative surface.