Primeira submissão em 09/11/10 Última submissão em 06/05/11 Aceito para publicação em 01/06/11 Publicado em 20/10/11

These data indicates a high prevalence (5.6%) of confirmed celiac disease in Down syndrome patients from southern Brazil.

No abstract

The results demonstrate a significant positivity of anti-CCP2 in relatives of RA patients from Brazil and reinforce the importance of serological tools to identify undiagnosed RA.

Data from the present study suggest that the high incidence of positive RF observed in DS patients might be related to the senescence of the immune system or could be an earlier marker of rheumatic diseases in these patients.