A new crystalline antibiotic, minimycin1), C9HnNO7,was isolated from the culture broth of Streptomyces hygroscopicus. Isolation and properties of the new antibiotic are described. Minimycin is active against both Gram-positive and Gram-negative bacteria, and also possesses significant antitumor activity against transplantable tumors.

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A new subspecies of Streptomyces hygroscopicus was isolated from a peatysoil collected in Bibai, Hokkaido, Japan in July, 1965, and numbered as 325-17. The isolate has been named Streptomyces hygroscopicus (Jensen) Waksman et Henrici subsp. aabomyceticus Seino. Freeze-dried cultures of the type strain

SHIRATO, SHIROH (Kaken Chemical Co., Ltd., Tokyo, Japan), AND HIROSHI MOTOYAMA. Fermentation studies with Streptomyces griseus II. Synthetic media for the production of streptomycin. Appl. Microbiol. 14:706-710. 1966.-Synthetic media for streptomycin fermentation were studied to determine which media gave highest yields of streptomycin. The effect of salts on streptomycin production by Streptomyces griseus was examined, and a suitable combination of salts was estab

Resistaphylin is a new antibacterial antibiotic produced by an identified species of Streptomyces antibioticus No. K-869. The active substance in the fermented broth can be isolated by solvent extraction followed by chromatography on an alumina column. It exhibits marked inhibitory activity against Gram-positive bacteria. Resistaphylin is a new antibiotic, because it differs from other antibiotics in certain physico-chemical properties. This communication describes the production, isolation and characterization of resistaphylin. Production and Isolation of Resistaphylin 1. Fermentation