We observe the high harmonic generation (HHG) from anti-aligned CO(2) molecules when the on-axis peak of HHG from HOMO-2 orbital disappears. The harmonic emission at anti-alignment can be attributed to the contribution of HOMO-1 orbital. Simulations reproduce these observations and reveal the angular distributions of tunneling ionization from HOMO and HOMO-1 respectively at different intensity. The determination of HOMO-1 orbital contributions in harmonic spectra is important for the tomography imaging of aligned molecules and analysis of the time evolved harmonic emission.

We experimentally demonstrate the generation of an extreme-ultraviolet (XUV) supercontinuum in argon with a two-color laser field consisting of an intense 7 fs pulse at 800 nm and a relatively weak 37 fs pulse at 400 nm. By controlling the relative time delay between the two laser pulses, we observe enhanced high-order harmonic generation as well as spectral broadening of the supercontinuum. A method to produce isolated attosecond pulses with variable width and intensity is proposed.

No abstract

No abstract

Objective: Drawing a growth curve of multidrug-resistant Pseudomonas aeruginosa (MDR-PA) provides a foundation for susceptibility testing. By observing in vitro antibacterial activity and ultrastructure cthanges on MDR-PA of the effective components in the drug-containing serum of rats after the administration of Fuzheng Jiedu Huayu decoction (FJHD), we evaluated the inhibition and direct destruction effect of bacteria by TCM alone or combined with antibiotics. Methods: The absorbance values of MDR-PA were determined at different detection time points, and a growth curve was drawn. After gavage with FJHD, drug-containing serum was collected from the rats. Using Imipenem/cilastatin sodium as the positive drug control, the in vitro antibacterial potency of FJHD and its drug-containing serum alone or in combination with antibiotics against MDR-PA was observed. The ultrastructural changes of MDR-PA treated by FJHD combined with antibiotics were observed by transmission electron microscopy. Results: Growth of the experimental strain manifested a lag phase in the first 1-4 h, an exponential growth phase at 5-20 h, and a plateau phase after 20 h. The best detection time during the susceptibility test was 16-20 h. The minimum inhibitory concentration (MIC) value of the FJHD extract group was 0.2 g/mL. The MIC value of the pure Imipenem/ cilastatin sodium group was 16 mg/mL. The MIC values of Imipenem/cilastatin sodium + blank serum, 0.5-, 1-, and 2-fold drug-containing serum groups were all 16 mg/mL. The MIC values of Imipenem/cilastatin sodium + 4-and 8-fold drug-containing serum groups were both 8 mg/mL. By observation under a transmission electron microscope, Imipenem/ cilastatin sodium + 0.5-, 1-, and 2-fold drug-containing serum groups showed bacterial structural damage. The degree of bacterial destruction was more obvious and the quantity