Leukodystrophy cases are not common in routine clinical practice. Among leukodystrophies adrenoleukodystrophy (ALD) cases are more common. It presents with neurologic and endocrine features with characteristic Megnetic Resonance Image (MRI) findings and biochemical changes. Early recognition of index case is important because dietary modification & supplementation with Lorenzo’s oil can slow progression of the disease course and can be life saving. Bone Marrow Transplantation (BMT) if performed in earlier stage of disease can be very rewarding to show stabilization and in some instances improvement of patient’s condition. More over prenatal diagnosis of affected boys can be performed by analyzing pedigree chart of an affected family members of this X-linked chromosomal disease. JCMCTA 2016 ; 27 (1) : 68 - 71

Background: Cerebrospinal Fluid (CSF) examination is a common investigation to diagnose and evaluate different neurological diseases. The gold standard method of CSF examination is microscopy, biochemistry and culture in a standard laboratory, which require an experienced microscopist and laboratory support. Urinary reagent strip can be a point of care test in such condition. The study aimed to document the diagnostic accuracy of urinary reagent strip for the semi-quantitative analysis of CSF chemistry and cellularity. Materials and methods: One hundred hospitalized patients from the Department of Neurology, Chittagong Medical College Hospital were included in this study. CSF samples of the patients were subjected for the de nitive test (CSF microscopy and laboratory biochemical values) and the index test [Combur-10 urinary reagent strip was used as the index test for protein, glucose, leukocytes and erythrocytes. The diagnostic accuracy of each index test was calculated using different cut-off levels (Glucose 1+ vs. CSF glucose >50 mg/dL, protein 1+ vs. CSF protein >30 mg/dL, leukocyte esterase 1+ positivity vs. >10 granulocytes/mm3 and erythrocyte 1+ positivity versus >5 RBC/mm3 in CSF sample). Results: The diagnostic accuracy of protein estimation by reagent strip shows 100% sensitivity, 84.21% specificity for detection of CSF protein at level 30mg/dl. Glucose reagent strip positivity had 98.8% sensitivity and 75% specificity for detection of CSF glucose at level 50 mg/dl. Leukocyte esterase positivity by test strip had sensitivity of 60% and specificity of 100% for the detection of CSF granulocyte of >10 granulocytes/mm3. The diagnostic accuracy of erythrocyte estimation by reagent strip show 92% sensitivity, 92% specificity for detection of CSF RBC >5 cells/mm3. Conclusion: Urinary reagent strip can be used routinely for rapid analysis of CSF.A resource-limited hospital might find it useful as a point-of-care laboratory workup of CSF. Chatt Maa Shi Hosp Med Coll J; Vol.21 (2); July 2022; Page 9-13

Background:Prognosticating the outcome of Intracerebral Hemorrhage (ICH) at the time of admission is important to customize treatment in a cost-effective manner in such cases. ICH sore is a widely used prognosticating tool but yet not evaluated in our setting. This study was aimed to assess the prognostic factors influencing outcome and validating the ICH score for prediction of 30-day mortalityin hospitalized patients with ICH. Materials and methods:This prospective observational study was conducted in Chittagong Medical College Hospital, Bangladesh among 105 consecutively admitted patients aged 18 years and above with a computed tomography evidence of spontaneous ICH. ICH score was calculated soon after confirmation of diagnosis. Primary outcome measure was 30-day mortality after admission. Modified Rankin Scale (mRS) was used to assess outcome at discharge and at 30-day follow up. Results:A total of 104 patients were analyzed. Mean age of this cohort was 59.30±19.91 years. At 30 days all 27 patients with an ICH score of 0 survived, whereas those having scores of 1, 2, 3, and 4 had 5.9%, 33.3%, 46.2% and 88.9% mortality, respectively. ICH score was good for discriminating 30-day mortality with having an area under the ROC curve of 0.886 (95% CI:0.816-0.956; p<0.001]. For patients scoring above 2, the rate of poor functional outcome (mRS score e”4) approaches 100%. On the other hand, 18.5% of patients with score of 0 and 64.7% of patients with a score of 1 are not functionally independent after 30 days. Conclusion:In conclusion, the present study has demonstrated that the ICH score is a strong prognostic indicator of ICH outcomes (30-day mortality and 30- day functional outcome) among hospitalized patients in Bangladesh. Bangladesh Journal of Neuroscience 2019; Vol. 35 (2): 78-85