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From the beginning of humanity, people have relied on the usage of biotech-based products. Bioentrepreneurship or BioE is the drive of knowledge and innovation, traveling from academic world to industrial platform. In contrast to enterprise, bio-enterprise is the amalgamation of bioscience with business by the application of biological concepts or scientific entities for the benefit and the creation of a corporation. It is a strictly monitored industry because of involved scientific risks, time demands, and ethical clearance, as well as requiring huge capital. Every successful entrepreneur showcases certain traits that they have inculcated or relied on to build their business. These traits are not mere skills, but are the qualities that contribute in becoming an ideal bio-entrepreneur. The chapter deals with striking features of bio-entrepreneurs that have made them a conglomerate of global standard and play an essential role in making them leaders.