Key Points Question Is incidental use of a nonselective β-blocker (nsBB) at the time of surgery associated with a reduced rate of treatment for prostate cancer recurrence in patients who have undergone radical prostatectomy? Findings In this cohort study of 11 117 patients with prostate cancer undergoing radical prostatectomy, use of an nsBB at the time of surgery was significantly associated with a lower rate of treatment for prostate cancer recurrence. Meaning These results suggest that perioperative use of an nsBB at the time of radical prostatectomy may reduce the risk of prostate cancer recurrence, although randomized clinical trials are needed to answer this question.

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