Objectives: Evaluation of the impact of pharmaceutical care on improving knowledge and medication adherence in Chronic Kidney Disease (CKD) patients.Methods: Patient data were recorded on a data collection form after informed consent. Their knowledge and medication adherence were evaluated by questionnaire and it was quantified. Patients were counselled using patient information leaflets. Re-assessment was made during follow-up.Results: Medication adherence among patients was classified as low, medium and high adherence. Knowledge was classified under three categories excellent, average and poor. There was a considerable improvement in knowledge and medication adherence irrespective of age and gender. The study was statistically significant with P<0.05. Conclusion:The efforts to increase awareness on CKD patients such as providing patient counselling and continuous education could enhance adherence to therapies and thus could improve clinical outcomes and quality of life.