Stationary sources of air pollution are disproportionately located in communities of colour, but the causes for this disparity are unclear. Here we assess whether racialized appraisals of investment risk (‘red-lining’) undertaken by the US federal Home Owners’ Loan Corporation in the 1930s influenced the subsequent siting of fossil fuel power plants. Across 8,871 neighbourhoods in 196 US urban areas, we observed a stepwise correlation between risk grade, number of power plants and cumulative quantity of power plant emissions upwind and within 5 km. Controlling for pre-existing power plants, neighbourhoods deemed ‘hazardous’ (D grade, ‘red-lined’) had a higher likelihood of a fossil fuel power plant being sited between 1940 and 1969 (72%), 1970 and 1999 (20%) and 2000 and 2019 (31%), and higher average present-day emissions of nitrous oxides (82%), sulfur dioxide (38%) and fine particulate matter (63%) compared with ‘declining’ (C-graded) neighbourhoods. Our results suggest racism in the housing market contributed to inequalities in present-day power plant emissions burdens.