In order to explore the law of major and extra serious traffic accidents on expressways in China, a total of 802 cases of major and extra serious traffic accidents on expressways in the past 10 years were collected, and statistical analysis was conducted from the aspects of time distribution, spatial distribution, accident form, and accident cause. The results show that in the past 10 years, the incidence and casualties of major and extra-serious traffic accidents on expressways have shown a fluctuating downward trend. In January, May, August, and November every year, between 6: 00 and 8: 00 every day is the highest incidence of accidents. The Guangxi Zhuang Autonomous Region, Heilongjiang Province, Fujian Province, and Anhui Province have more accidents. Vehicle collisions have the highest number of deaths, and rollover injuries have the highest rate. Human factors accounted for 72.1% of the causes of accidents, among which improper measures and speeding accounted for the largest proportion. Finally, according to the results of data statistical analysis, the corresponding control measures should be put forward in order to provide reference and technical support for the current highway traffic safety situation and safety management policy.

A total of 523 accident cases during 2018–2021 in China were studied in terms of accident year, region, road section, and time to reduce the probability of expressways mobile hazardous source transportation accidents. The characteristics and causes of accidents of moving hazardous sources on expressways are analyzed, and preventive measures are put forward. The results indicated that the number of expressways mobile hazardous source transportation accidents fluctuated less in the past four years. Provinces with a higher degree of industrialization are more prone to accidents, with 80.02% of accidents occurring on normal road sections. Summer is the high accident season and accidents are prone to occur at 7:00 and 8:00 every day. External factors cause 47.99% of accidents, liquid class mobile hazards quickly cause accidents, leakage accidents account for the heaviest proportion, and explosive accidents have the highest chance of causing secondary accidents. In order to reduce the probability of accidents, a comprehensive management framework suitable for the mobile hazard sources of expressways is proposed.